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Iran on Tuesday rejected as "unacceptable" U.S. President Barack Obama's demand that it freeze sensitive nuclear activities for at least 10 years, but said it would continue talks aimed at securing a deal, Iran's semi-official Fars news agency reported.

Pakistan authorities have arrested hundreds of parents who refuse to vaccinate their children against polio, officials said Tuesday, as community opposition and Taliban threats block efforts to eradicate the crippling disease in one of its last strongholds.

Thousands of Iraqi soldiers and Shi'ite militiamen sought to seal off Islamic State fighters in Tikrit and nearby towns on Tuesday, the second day of Iraq's biggest offensive yet against a stronghold of the radical Sunni Islamist militants.