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Charges against a high-frequency trader for helping to spark the 2010 "flash crash" present a test of U.S. prosecutors' ability to win a big market manipulation case and may make other traders nervous they may be next, lawyers said on Tuesday.

The timing and scope of sanctions relief are among crucial sticking points as Iran and the six major world powers resume talks in Vienna on Wednesday to discuss a nuclear agreement aimed at curbing Tehran's nuclear activities by June 30.

The U.S. Drug Enforcement Administration's chief will step down within weeks, the Obama administration said on Tuesday, as a congressional panel planned to examine whether DEA agents divulged secrets at sex parties that Colombian drug lords may have staged.